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Many "Web 2.0" applications suffer from too-tight-coupling between the various javascript objects used to model the data and control the interface. This has always been seen as a necessary evil because there seemed to be no good alternative.
One common solution in desktop applications is called "event driven programming." Not just user-supplied events like mouse clicks, hovers, and window scrolls (obviously, we do all of that in our javascript apps already), but actual data-driven or state-driven events such as "message selected" or "preference changed".
Truly custom events, when used correctly, allow you to decouple many of the objects in your application. This leads to better self-containment and maintainability.
